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Salivary Diagnostic Biomarkers For Obstructive Sleep Apnea - A Systematic Review
Obstructive sleep apnea (OSA) is a highly prevalent disease, affecting individuals of all ages, and is a risk factor for cognitive disorders, metabolic disorders and cardiovascular diseases. Despite its impact on general health and quality of life, it remains underdiagnosed due to the high costs, and limited access to polysomnography.
The aim of this systematic review was to evaluate the diagnostic value of salivary biomarkers in OSA compared to full-night polysomnography performed in a sleep laboratory.
Studies that compared healthy individuals and those with apnea, were based on polysomnographic results, and without restriction on age, language or year of publication were eligible for inclusion. This review was registered in PROSPERO under the number: CRD42016037278, adhered to the PRISMA check list and used QUADAS as a tool to evaluate methodological quality and calculate the risk of bias. We consulted: PubMed, Embase, MEDLINE, LILACS, BBO-ODO, Cochrane and Google scholar.
We found 232 studies, 15 of which were included for detailed analysis and extraction of salivary biomarker diagnostic predictors for OSA. However, 13 were excluded because they did not report sensitivity and specificity. This review suggests that α-amylase and the alpha-2-HS- glycoprotein protein are potential salivary biomarkers.
Although more studies are needed to confirm the observed results, we can say that salivary biomarkers associated with the phenotypic pattern of OSA are a potential simple, low-cost alternative diagnostic method.
Saliva; Polysomnography; sleep-disordered breathing; Sleep Apnea, Obstructive; salivary biomarkers
Faculdade de Odontologia - Universidade Federal de Uberlandia - Minas Gerais - Brasil
THAYS CROSARA ABRAHÃO CUNHA, MARIA CECÍLIA MONTEIRO MAGALHÃES, FERNANDA BACCHIN, THULIO M CUNHA, ALFREDO JULIO FERNANDES-NETO, ROBINSON SABINO SILVA, PAULO CEZAR SIMAMOTO-JUNIOR