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Association of LEP-rs7799039 and ADIPOQ-rs2241766 polymorphisms with sleep quality in 4- and 6-year-old children: The PREDI Study.


Sleep disorders in children can be identified through several parameters, including sleep duration and sleep quality. Changes in the circadian cycle are an important characteristic associated with children’s sleep disorders. Some studies suggest that alterations in the secretion of leptin and adiponectin may influence the circadian cycle in children. The LEP-rs7799039 and ADIPOQ-rs2241766 polymorphisms are associated with leptin and adiponectin secretion, and thus may influence the child’s sleep quality


The aim of this study was to evaluate the association of the leptin rs7799039 and adiponectin rs2241766 gene polymorphisms with sleep quality in 4- and 6-year-old children.


Data were obtained from the “Predictors of Maternal and Child Excess Body Weight - PREDI Study”, a larger cohort study conducted in Joinville – Brazil (baseline in 2012). The current study is a cross-sectional study, which was carried out in the homes of the participants between July 2016 and August 2017 (2nd Follow-up, 4 years old), and in 2018 (3rd Follow-up, 6 years old). The sleep quality was assessed by the “Sleep Habits Inventory for Preschool Children”, self-reported by the mothers. The minimum score on the Sleep Habits Inventory was considered as a better sleep quality. Genotyping analysis was performed in blood samples by the polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) technique.


There was no statistically significant association of the ADIPOQ or LEP gene polymorphism with sleep quality at 4 and 6 years of age. However, carriers of at least one risk allele (TG+GG) of the ADIPOQ gene polymorphism were more prevalent among children with poor sleep quality when compared to those carrying the wild-type genotype (TT), in both 4- and 6-year-olds (42.3% vs 28.4%, p=0.06; 32.6% vs 19.2%, p=0.07, respectively).


Poor sleep quality in children at 4 and 6 years of age may be influenced by the adiponectin rs2241766 gene polymorphism. New studies involving a larger number of children are needed to better explain the relationship between sleep quality and adiponectin polymorphism.


Sleep Quality, Middle Childhood, Leptin, Adiponectin, Polymorphisms, ADIPOQ-rs2241766, LEP-rs7799039.


Área Básica


Melody Cristina Mansani Carraro Trombelli, Caroline Kroll, Lidiane Ferreira Schultz, Renatha El Rafihi Ferreira, Silmara Salete de Barros Silva Mastroeni, Marco Fabio Mastroeni